DEA Form 222 vs CSOS for Veterinary Schedule II Ordering

When Form 222 or CSOS is required

A DEA Form 222 or its electronic equivalent is required for each distribution of a Schedule I or II controlled substance, unless a specific exception applies. ¹

A registrant authorized to obtain DEA Form 222 may requisition order forms from DEA. ²

CSOS is the electronic ordering path for Schedule I and II substances, and electronic orders must meet the requirements in Part 1305 Subpart C. ³

Who may sign

A purchaser must prepare and execute a DEA Form 222 by typewriter, computer printer, pen, or indelible pencil. ⁴

The order may be signed by the registrant, an authorized partner or officer, or a person granted power of attorney under 21 CFR 1305.05. ^{4 5}

A registrant may authorize one or more individuals to issue Schedule II orders by executing a power of attorney for each person and retaining it in the files. ⁵

Records to keep

A purchaser must retain a copy of each executed DEA Form 222 and all copies of unaccepted or defective forms with statements attached. ⁶

Form 222 records must be kept separately from all other records and at the registered location printed on the form. ⁶

A Form 222 is not valid more than 60 days after execution by the purchaser. ⁷